Because of the non-linear dependence of volumetric flow rate on pore size … where t is the membrane thickness and r is the pore radius, large pores contribute disproportionately to the total flow through a membrane than small pores. The…
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NPN Clogging with Particle Size and Concentration (FOW)
This figure appears in our 2016 JMS paper and describes the clogging behavior of NPN with a 37 nm average pore size. The y-axis is the volume of filtrate after 1 min of forward centrifugation at 690g (3000 RPM). The…
The Rate of Protein Binding to Surfaces
When we coat surfaces or particles with proteins we often wonder, ‘how long until the coating is done? ‘ In this 2009 paper we addressed the question directly. We soaked 100 nm polystyrene particles in 10% serum (about 6 mg/ml…
Nanoparticle Concentrations
Knowledge of the particle number is critical in many of our applications. In trying to rationalize membrane ‘clogging’ by particles for example, it is wise to compare the particle density to pore density at the membrane. When conjugating protein to…
Clearance, Kt/V, and Concentration in a Reverse Flow Dialyser
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