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Publications

2025

  • Linares, I., Chen, K., Saffren, A., Mansouri, M., Abhyankar, V.V., Miller, B.L., Begolo, S., Awad, H.A., McGrath, J.L., (2025) Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis. Scientific Reports. 15:3227. https://doi.org/10.1038/s41598-025-85987-z
  • Ajalik, R.E., Linares, I., Alenchery, R.G., Zhang, V.Z., Wright, T.W., Miller, B.L., McGrath, J.L., Awad, H.A., (2025) Human Tendon‐on‐a‐Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis. Advanced Healthcare Materials. 14:2403116. https://doi.org/10.1002/adhm.202403116

2024

  • Ahmad, S.D., Linares, I., Pietropaoli, A., Waugh, R.E., McGrath J.L. (2024) Sided Stimulation of Endothelial Cells Modulates Neutrophil Trafficking in an in vitro Sepsis Model Advanced Healthcare Materials, 2304338; doi: 10.1002/adhm.202304338
  • Mehran Mansouri, M., Aidan R. Hughes, A.R., Lauren A. Audi, L.A., Anna E. Carter, A.E., Justin A. Vidas, J.A., McGrath, J.L., Abhyankar, V.V., (2024) Transforming Static Barrier Tissue Models into Dynamic Microphysiological Systems, J. Vis. Exp. (204), e66090, doi:10.3791/66090
  • McCloskey, M. C., Kasap, P., Trempel, M., Widom, L. P., Kuebel, J., Chen, K., Gaborski, T. R., Engelhardt, B., McGrath, J. L. (2024) Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. J. Vis. Exp. (203), e65258, doi:10.3791/65258

2023

  • Shargh, A. K. and N. Abdolrahim (2023). “An interpretable deep learning approach for designing nanoporous silicon nitride membranes with tunable mechanical properties.” npj Computational Materials 9. https://www.nature.com/articles/s41524-023-01037-0
  • Soldati, S., A. Bär, M. Vladymyrov, D. Glavin, J. L. McGrath, F. Gosselet, H. Nishihara, S. Goelz and B. Engelhardt (2023). High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro. Journal of Neuroinflammation 20(1):123. https://10.1186/s12974-023-02797-8
  • Ahmad, S. D., Cetin, M., Waugh, R. E. & McGrath, J. L. (2023) A computer vision approach for analyzing label free leukocyte trafficking dynamics on a microvascular mimetic. Frontiers in Immunology 14. https://10.3389/fimmu.2023.1140395
  • S. Gholizadeh, D.M. Lincoln, Z. Allahyari, L.P. Widom, R.N. Carter, T.R. Gaborski, (2023) Optimization of Parylene C and Parylene N thin films for use in cellular co-culture and tissue barrier models, Scientific Reports 13:4262. https://doi.org/10.1038/s41598-023-31305-4
  • Hudecz, D., McCloskey, M.C., Vergo, S., Christensen, S., McGrath, J.L., Nielsen, M.S. (2023) Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device. International Journal of Molecular Sciences 24:5624. https://10.3390/ijms24065624

2022

  • McCloskey, M.C., Zhang, V.Z. Ahmad, S.D., Walker, Romanick, S.S., Awad, H.A., and McGrath, J.L. (2022) Sourcing cells for in vitro models of human vascular barriers of inflammation, Frontiers in Medical Technology, 4: 979768. https://doi: 10.3389/fmedt.2022.979768
  • Su, S.H., Song, Y., Stephens, A., Situ, M., McCloskey, M.C., McGrath, J.L., Andjelkovic, A.V., Singer, B.H., and Kurabayashi, K. (2023) A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring, Biosensors and Bioelectronics, 224: 115030 https://doi.org/10.1016/j.bios.2022.115030
  • Cognetti, J. S., M. T. Moen, M. G. Brewer, M. R. Bryan, J. D. Tice, J. L. McGrath, and B. L. Miller. (2023) A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers, Lab Chip. 23: 239-250 https://DOI: 10.1039/d2lc00864e
  • Young, M., Walsh, D.J., Masters, E., Gondil, V.S., Laskey, E., Klaczko, M., Awad, H., McGrath, J.L., Schwarz, E.M., Melander, C., and Dunman, P.M., (2022) Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors, Antibiotics 11: 1351 https://doi.org/10.3390/antibiotics11101351
  • Hsu, M. C., M. Mansouri, N. N. N. Ahamed, S. M. Larson, I. M. Joshi, A. Ahmed, D. A. Borkholder, and V. V. Abhyankar. 2022. ‘A miniaturized 3D printed pressure regulator (microPR) for microfluidic cell culture applications’, Sci Rep, 12: 10769. https://doi.org/10.1038/s41598-022-15087-9
  • Mansouri, M., Ahmed, A., Ahmad, D., McCloskey, M.C., Joshi, I.M., Gaborski, T.R., Richard E Waugh, R.E., McGrath, J.L., Day, S.W., Abhyankar V.V. (2022) The Modular μSiM Reconfigured: Integration of Microfluidic Capabilities to Study in vitro Barrier Tissue Models Under Flow Advanced Healthcare Materials e2200802 https://doi.org/10.1002/adhm.202200802
  • McCloskey, M.C., Kasap, P., Ahmad, D.P.S., Su, SH., Chen, K., Mansouri, M. Ramesh, R., Hideaki Nishihara, Belyaev, Y., Abhyankar, V.V., Begolo, S., Singer, B.H., Webb, K.F., Kurabayashi, K., Flax, J., Waugh, R.E., Engelhardt, B., McGrath J.L. (2022) The Modular μSiM: a Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro Advanced Healthcare Materials e2200804 https://doi.org/10.1002/adhm.202200804
  • Allahyari, Z., Casillo, S. M., Perry, S. J. , Peredo, A. P. , Gholizadeh, S. , and Gaborski, T.R. (2022) Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization and Enhance Adipogenesis through Morphological Changes, ACS Biomater Sci Eng, 8: 1791-98.
  • Allahyari, Z., and Gaborski, T. R. (2022) Engineering cell-substrate interactions on porous membranes for microphysiological systems, Lab Chip, 22: 2080-89.
  • Salminen, A.T., McCloskey, M.C., Ahmad, S.D., Romanick, S.S., Chen., K., Houlihan, W., Klaczko, M.E., Flax, J., Waugh, R.E., McGrath, J.L., Molecular Mechanisms Underlying the Heterogeneous Barrier Responses of Two Primary Endothelial Cell Types to Sphingosine-1-Phosphate (2022) European Journal of Cell Biology 101: 151233 https://doi.org/10.1016/j.ejcb.2022.151233
  • Ajalik, R.E., Alenchery, R.G., Cognetti, J.S., Zhang, V.Z., McGrath, J.L., Miller, B.L., and Awad, H.A., (2022) Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery, Frontiers in Bioengineering and Biotechnology, 10: 846230
  • Shargh, A.K., Madejski, G.R., McGrath, J.L., and Abdolrahim, N. (2022) Mechanical properties and deformation mechanisms of amorphous nanoporous silicon nitride membranes via combined atomistic simulations and experiments, Acta Materialia, 222: 17451 https://doi.org/10.1016/j.actamat.2021.117451

2021

  • Masters, E.A., Muthukrishnan, G., Ho, L., Gill, A.L, Karen Bentley, K., Chad A Galloway, C.A., McGrath, J.L., Awad, H., Steven Gill, S., Schwarz, E., (2021) Staphylococcus aureus Cell Wall Biosynthesis Genes Modulate Bone Invasion and Osteomyelitis Pathogenesis, Frontiers in Microbiology, 16;12:723498 doi:10.3389/fmicb.2021.723498 
  • Dias, M.C., Quesada, A.O., Soldati, S., Bösch, F., Gruber, I., Hildbrand, T., Sönmez, D., Khire, T. Witz, G., McGrath, JL, Piontek, J., Kondoh, M, Deutsch, U., Zuber, B., and Engelhardt, (2021) Brain endothelial tricellular junctions as novel sites for T-cell diapedesis across the blood-brain barrier. Journal of Cell Science, 134: jcs253880 https://doi: 10.1242/jcs.253880
  • Ahmed, A., Joshi, I. M., Larson, S., Mansouri, M., Gholizadeh, S., Allahyari, Z., Forouzandeh, F., Borkholder, D. A., Gaborski, T. R., Abhyankar, V. V., (2021) Microengineered 3D Collagen Gels with Independently Tunable Fiber Anisotropy and Directionality. Adv. Mater. Technol. , 2001186. https://doi.org/10.1002/admt.202001186

2020

  • Salminen AT, Allahyari Z, Gholizadeh S, McCloskey MC, Ajalik R, Cottle RN, Gaborski TR and McGrath JL (2020) In vitro Studies of Transendothelial Migration for Biological and Drug Discovery. Front. Med. Technol. 2:600616. https://doi.org/10.3389/fmedt.2020.600616
  • Gholizadeh, S., Z. Allahyari, R.N. Carter, L.F. Delgadillo, M. Blaquiere, F. Nouguier‐Morin, N. Marchi, and T.R. Gaborski, (2020) Robust and Gradient Thickness Porous Membranes for In Vitro Modeling of Physiological Barriers. Advanced Materials Technologies, https://doi.org/10.1002/admt.202000474
  • Salminen, A.T., Tithof, J., Izhiman, Y., Masters, E.A., McCloskey, M.C., Gaborski, T.R., Kelley, D.H., Pietropaoli, A.P., Waugh, R.E., McGrath, J.L. (2020) Endothelial Cell Apicobasal Polarity Facilitates Distinct IL-8 Secretion and Immune Responses to Systemic vs. Local Inflammation, Integrative Biology, 12(11),275–289, https://doi.org/10.1093/intbio/zyaa022
  • Masters EA, de Mesy Bentley KL, Gill AL, Hao SP, Galloway CA, Salminen AT, Guy, D.R., McGrath, J.L., Awad, H.A., Gill, S.R., Schwarz, E.M. (2020) Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice. PLoS Pathog 16(10): e1008988. https://doi.org/10.1371/journal.ppat.1008988
  • Khire, T.S., Salminen, A.T., Swamy, H., Lucas, K.S., McCloskey, M.C., Ajalik, R.E., Chung, H.H, Gaborski, T.R., Waugh, R.E., Glading, A.J., McGrath, J.L., (2020) Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions  Cell and Molecular Bioengineering 13: 125–139
  • Hudecz, H., Khire, K., Chung, H.L., Adumeau, L., Glavin, D., Luke, E.N., Nielsen, M.S., Dawson, K.A., McGrath, J.L., Yan, Y. (2020) Porous Silicon Nitride Membranes for in situ Optical Analysis of Translocation of Nanoparticles across the Blood-Brain Barrier ACS Nano 14: 1111-1122
  • Allahyari, Z, Gholizadeh, S. Chung, H.L., Delgadillo, L., Gaborski, T.R. (2020) Micropatterned PEG islands disrupt endothelial cell-substrate interactions differently from microporous membranes ACS Biomater. Sci. Eng. 6:959-968

2019

  • Masters, E.A., Salminen, A.T., Begolo, S., Luke, E.N., Barrett, S., Overby, O.T., Gill, A.L., de Mesy Bentley, K.L., Awad, H.A., Gill, S.R., Schwarz,, E.S., McGrath, J.L. (2019) An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis. Nanomedicine 21:102039
  • Salminen, A.T., Zhang, J., Madejski, G.R., Khire, T.S, Waugh, R.E., McGrath, J.L., Gaborski T.R. (2019) Ultrathin Dual-Scale Nano- and Micro-Porous Membranes for Vascular Transmigration Models. Small 5(6):e1804111
  • Mossu, A., Rosito, M., Khire, T., Chung, H.H., Nishihara, H., Gruber, I., Luke, E., Dehouck, L., Sallusto, F., Gosselet, F., McGrath, J.L., Engelhardt, B.  (2019) A Silicon Nanomembrane Platform for the Visualization of Immune Cell Trafficking Across the Human Blood-brain Barrier Under Flow. Journal of Cerebral Blood Flow & Metabolism 39(3):395-410

2018

  • Chung, H.H. , Mireles, M. BJ Kwarta, TR Gaborski (2018) Use of Porous Membranes in Tissue Barrier and Co-culture Models. Lab on a Chip 18:1671-1689
  • Khire, T, Nehilla, B.J., Getpreecharsawas, J., Gracheva, M.E., Waugh, R.E., McGrath, J.L., (2018) Finite Element Modeling to Analyze TEER Values Across Silicon Nanomembranes, Biomedical Microdevices 20:1-11
  • Chung, H.H., Casillo, S. M., Gaborski, T.R., (2018) Porous Substrates Promote Endothelial Migration at the Expense of Fibronectin Fibrillogenesis. ACS Biomater Sci Eng 4:222-230.

2017

  • Casillo, S. M., Peredo, A. P., Perry, S. J., Chung, H. H.; Gaborski, T.R., (2017) Membrane Pore Spacing Can Modulate Endothelial Cell-Substrate and Cell-Cell Interactions. ACS Biomater Sci Eng 3: 243-248.
  • Carter, R. N., Casillo, S. M., Mazzocchi, A. R.; DesOrmeaux, J. S., Roussie, J. A., Gaborski, T. R., (2017) Ultrathin transparent membranes for cellular barrier and co-culture models. Biofabrication 9: 015019.
  • Bentley, K., Trombetta, R., Nishitani, K, Bello-Irizarry, S.N., Ninomiya, M, Chung, H.L., McGrath, J.L., Daiss, J.L., Awad, A.A., Kates, S.L., Schwarz, E.M. (2017) Evidence of Staphylococcus aureus deformation, proliferation and migration in surgery-induced microcracks and canaliculi of live cortical bone in murine models of osteomyelitis. Journal of Bone and Mineral Research, 32:985-990
  • Gilmer, S.R., Fang D.Z., Wayson, S.E., Winans, J.D., Abdolrahim, N., DesOrmeaux, J.P.S, Getpreecharsawas, J., Ellis, J.D., Fauchet, P.M., McGrath, J.L., (2017) Predicting the failure of ultrathin porous membranes in bulge tests, Thin Solid Films, 631: 152-160
  • Li, X., Johnson, D., Ma, W., Chung, H., Getpreecharsawas, J., McGrath, J.L., Shestapalov, A.A., (2017) Modification of Nanoporous Silicon Nitride with Stable and Functional Organic Monolayers, Chem. Mater., 29: 2294–2302

2016 and earlier

  • Winans, J., Smith, K., Gaborski, T.R., Roussie, J., McGrath, J.L., (2016) Membrane capacity and fouling mechanisms for ultrathin nanomembranes in dead-end filtration. J. Mem. Sci. 499: 282-289
  • Qi C, Striemer CC, Gaborski TR, McGrath JL, Fauchet PM. (2015) Influence of Silicon Dioxide Capping layers on pore characteristics in nanocrystalline silicon membranes. Nanotechnology 26: 055706
  • Getpreecharsawas, J., McGrath, J.L., Borkholder, D. (2015). The electric field strength in orifice-like nanopores of ultrathin membranes. Nanotechnology 26: 045704
  • Miller, J. J.; Carter, R. N.; McNabb, K. B.; DesOrmeaux, J. P. S.; Striemer, C. C.; Winans, J. D.; Gaborski, T. R., (2015) Lift-off of large-scale ultrathin nanomembranes. J Micromech Microeng 25: 015011.
  • Mazzocchi, A. R.; Man, A. J., DesOrmeaux, J. P. S., Gaborski, T. R., (2014) Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions. Cel. Mol. Bioeng.  7 (3), 369-378.
  • Nehilla, B.J., Nataraj, N., Gaborski, T.R., McGrath, J.L. (2014) Endothelial Vacuolization Induced By Highly Permeable Nanoporous Substrates, Acta Biomaterialia 10:4670-4677
  • DesOrmeaux, J. P., Winans, J. D., Wayson, S. E., Gaborski, T. R. , Khire, T. S., Striemer, C. C., and McGrath, J. L. (2014) Nanoporous silicon nitride membranes fabricated from porous nanocrystalline silicon templates, Nanoscale 6:10798-10805
  • Chung, H.H., Chan, C.K., Khire, T.S., Clark Jr., A., Waugh, R.E., McGrath, J.L. (2014) Highly Permeable Silicon Membranes for Shear Fee Chemotaxis and Rapid Cell Labeling, Lab on a Chip 14:2456-68
  • Qi C, , Striemer CC, Gaborski TR, McGrath JL, Fauchet PM. (2014) Highly Porous Silicon Membranes Fabricated from Silicon Nitride/Silicon Stacks. Small 10:2946-53
  • Agrawal, A.A., Nehilla, B.J., Reisig, K.V. , Gaborski, T.R., Fang, D.Z, Striemer, C.C., Fauchet, P.M., and McGrath, J.L. (2010) Porous nanocrystalline silicon membranes as highly permeable and molecularly thin substrates for cell culture. Biomaterials 31: 5408-5417, PMCID: 2039892
  • Striemer, C.S, Gaborski, T.R., McGrath, J.L., Fauchet, P.M, (2007) Size and charge based separation of macromolecules using ultrathin silicon membranes, Nature 445:749-53