Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since. This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.

Darcy’s Permeability

Darcy’s Law relates the volumetric flow rate Q through a porous media in response to a pressure gradient . … Where is the intrinsic permeability of the media, is the fluid viscosity, L is the length of the media that

Posted in Knowledge (Public)

Pressure Distribution and Membrane Deflection During EO

The pressure distribution during EO is a little counter-intuitive. Assuming no back pressure, and neglecting the effects of the meniscus on either end of an EO channel, the pressure distribution relative to the (left-to-right) direction of flow must look something

Posted in NRG

Hydraulic Permeability

The hydraulic permeability of a membrane is the inverse of the fluid resistance normalized to the membrane area. Experimentally it is found with Where Q is the measured flow rate, is the pressure drop across the membrane and is the

Posted in NRG

Lab Floors Getting Cleaned on Feb 22

Please plan accordingly and be sure all moveable items are off the floor the night before.

Posted in NRG

EO w/pnc-Si at Louisville

Cindy Hartnett – professor of mechanical engineering at Louisville requested some pnc-Si chips after reading our PNAS paper. In requesting the material she mentioned … I’ve long been searching for a low-voltage way to drive some micro-actuators. Electrokinetic pumps looked

Posted in NRG

Endothelial Vacuoles Induced by Flow

In working on a long over due paper by Barrett on endothelial response to high permeability material … Key figs … Figure 2 Figure 4 Figure 5 And one post from Nakul. I came across this highly relevant paper Pedrigi(Overby)EER11

Posted in NRG

Filtration of DNA and Bugs @ INT

Two experiments were performed to explore application of SiMPore filters within INT’s microfluidic cartridges to allow the capability for pathogen type specificity in nucleic acid purification. 1) The first experiment tested the efficiency at which nucleic acids could pass through

Posted in NRG

MATLAB Installation

Good morning, We received some messages from customer who are having trouble logging into their Matlab account. If you are having trouble accessing Matlab, please see below for your update instructions. If you continue to have Matlab issues, please contact

Posted in NRG

Problems with lab door

Can someone help explain this e-mail? Hey Jim – Just got a call from the locksmith who had a report from security that someone in your lab is tampering with the lock on your lab door…by doing what they’re doing,

Posted in NRG

Viscosity vs. [BSA]

 Are you wondering why Dean has yet to go beyond 30% BSA in his clearance studies? Here is why … APP-04_Viscosity-of-BSA-in-PBS.pdf

Posted in NRG
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