Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since. This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.

Coulter Project Timeline

Posted in NRG

EO as a function of pore radius

From Jess’ manuscript … From Wikipedia … From Tom’s ACS nano paper … The Dagan equation (2) for flow through short pores used to predict flow through pnc-Si is given by: where r is the average pore radius, DP is

Posted in NRG

Impact of membrane thickness on EO

One of the surprising results of Jiracai’s studies with thick and thin membranes was that the thicker membranes had a lower capacity to support back pressure than the thinner membranes he used (see table in this post). This is counter

Posted in NRG

Efficiency of EO

Jirchai summarized his data in this table … A question raised by a reviewer of our PNAS submission – and one that we’ve had for a long time – is what is the efficiency of the pump. The electrical power

Posted in NRG

EO Pressure/Flow Relationship

When we submitted the EO paper way back one of the reviewers made the following comment … What is the “head pressure” P_max, i.e. the maximum back pressure that would stop the pump? For any linear electrokinetic phenomenon such as

Posted in NRG

Coulter Foundation Presentation

On Monday I presented our progress on the hemodialysis project for the Coulter Foundation. They seemed very pleased with our progress and impressed with our team. Its a tough crowd and for the first time, I sensed they had confidence

Posted in NRG

EO Update

On the 13th of September we reviewed our recent progress on EO. Maryna and Jirachai (Borkholder group) gave presentations. I’ve uploaded PDF files of each of their presentations. Maryna’s presentation: MarynaEO Jarachai’s presentation: EO_Testing_Report (PPT) EO_Testing_Report (PDF) Bubble formation in

Posted in NRG

Thermodynamic Efficiency of EO with pnc-Si

EO permeability: We often refer to the ‘efficiency’ of EO with pnc-Si as being very high, but this may not be the case. What is actually high, as in the case of the other modes of transport, is the ‘permeability’

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Status the 'Harold Smith' Project

This is my attempt to summarize where we are with our investigation into the use of membrane arrays in high throughput screening. The effort is known colloquially as the ‘Harold Smith Project’ because the model protein system comes from Harold

Posted in NRG

A Different Look at Shigeru's Latest

The paper that came out from Shigeru’s laboratory earlier this year in Analyitical Chemistry (Ishimatsu et al. 2010 downloadable here) demonstrated that the permeability of pnc-Si membranes to small monovalent ions in 0.1 M salt is predictable from membrane geometry

Posted in NRG
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