Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since. This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.

Why TEER Values are Multiplied by Membrane Area (DC Version)

Transendothelial electrical resistance measurements are expressed in the units . Where the measured resistance is multiplied by the area of the membrane to enable a comparison between measurements in different systems. We have often wondered why, but the reasoning for

Posted in NRG

NPN as an integrated filter for a NP Sensor

Last fall we decided to try to integrate a filter immediately upstream of Vincent Tabard-Cossa’s nanopore DNA sensors. The idea is to assemble back-to-back a NPN membrane a standard nitride membrane used in Vincent’s nanopore fabrication system an oxide spacer.

Posted in NRG

Summary of recent changes

The blog has migrated to a new hosting provider. This means that the passwords for owncloud and the blog are no longer in sync. Owncloud has been upgraded from 5.0.18 to 7.0.4. The passwords have not been changed and are

Posted in NRG

Two ways to subscribe to the blog

There are now two ways to sign up to receive new blog content by e-mail. The original way was disabled for a few months, but is now back. This is the approach that creates a beautiful e-mail with full post

Posted in NRG

Protochips E-Chips

The company Protochips is making interesting microfluidic chips and systems for electron microscopy. See this page and this movie. Note their use of integrated spacers as thin as 150 nm to create a flow channel between back-to-back membrane chips. This

Posted in Knowledge

Journal Club for June 26

Very last minute but here goes … Voting closes at 7 pm tonight. Vote for 2! [yop_poll id=”4″]  

Posted in NRG

Effect of increasing dialysate flow rate on diffusive mass transfer of urea, phosphate and β2-microglobulin during clinical haemodialysis

Bhimani(Ward)10NDT This is a useful paper for our work on Hemodialysis. The authors examine the clearance rates of urea, B2 microglobulin and phosphate as a function of dialysate flow rate . Two things surprise me in this paper: 1) the

Posted in NRG

On the Efficiency of Center-Based Dialysis

The typical dialysis center experience targets a urea clearance value of KT/V = 1.4 (KT/V is explained by Dean here). We can use this knowledge to solve for the clearance rate of a typical dialysis center experience. Assuming 40 L

Posted in Knowledge

ASAIO Conference

Final-Program-MMD-2014.prog_ June 19 Random Notes •    Blood Stasis is the main cause of thrombosis •    23 French can access the venous system •    3 French per mm •    Extracorporal Membrane Oxygenator used in the treatment of Cardiogenic Shock ◦    Use

Posted in NRG

The Rate of Protein Binding to Surfaces

When we coat surfaces or particles with proteins we often wonder, ‘how long until the coating is done? ‘ In this 2009 paper we addressed the question directly. We soaked 100 nm polystyrene particles in 10% serum (about 6 mg/ml

Posted in Knowledge (Public)
0
    0
    Your Cart
    Your cart is emptyReturn to Shop