http://www.genengnews.com/insight-and-intelligence/silicon-ideal-to-culture-patient-on-a-chip/77900627/ Organs-on-Chips Remotely Monitored, Controlled via Google Glass
Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since.
This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.
Nair, R. R., et al. (2012). “Unimpeded permeation of water through helium-leak-tight graphene-based membranes.” Science 335(6067): 442-444.
Nair(Geim)Science12 Supplement Laminates of GO from 0.1 to 10 um thick on copper foil with an etched hole of 1 cm. Casually mentions >1.5 psi applied to materials < 1 um thick over 1 cm diameter hole. This seems to…
Posted in NRG
Imidazole functionalized graphene oxide/PEBAX mixed matrix membranes for efficient CO2 capture
SEPPUR-D-16-00198 Abstract Mixed matrix membranes (MMMs) were composed of imidazole functionalized graphene oxide (ImGO), a CO2-philic nano-sheet inorganic material, and poly(ether-b-amide) (PEBAX) for CO2 capture. MMM doped with 0.8 wt.% ImGO exhibits the best CO2 separation performance, which shows the…
Posted in NRG
CVB Conference in Paris (July ’15)
Program C. Gu – Harvard Seminal Experiments Reese and Karnolvsky 1967 Brightman and Reese (1969) Two unique features of CNS endothelium: Specialized tight junctions – Very low rate transcytosis. Tight Junction by EM Ben-Zvi et al 2014 Nature. Transcytosis becomes…
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Review: Ultrathin Silica Membranes with Highly Ordered and Perpendicular Nanochannels for Precise and Fast Molecular Separation
Xingyu et al; Supplement The authors of this submission to ACS Nano apply techniques for the creation of mesoporous silica thin films with vertically aligned nanochannels to create ultrathin (< 100 nm) silica membranes with ~ 2 nm nanochannels. The…
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NSF STTR Goals
Phase II submission August 1, 2016 or January 30, 2017 UR Tasks – Biocompatibility by Feb. 1 2016 Channel design optimization by November 2015
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Sepsis Retreat
9:10 – 9:55am Tony Pietropaoli Must drink liters of water but not urinating. Retaining. Massive edema. Cases that recover must absorb 1/3 to 1/2 of all patient deaths in hospital are related to sepsis. May be an…
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Heart on a Chip (Healy Group)
Kevin Healy is a Phase I and Phase II awardee of the NIH Tissue Chip initiative. The goal of this initiative is to create ‘mini-organs’ ‘organs-on-a-chip’ ’tissue chips’ or ‘microphysiological systems’ (MPS) for higher throughput and more reliable drug discovery.…
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Simple Sieving Results
I used the following parameters in the Simple Sieving Model (pardon the MATLAB syntax) Am = 1; %cross sectional area in cm^2 Do = 1*10^-7;% diffusion coefficient in the membrane in cm^2/sec P = .15;% membrane porosity; t = linspace(0,420,500);…
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Simple Sieving Model
In an effort to better understand and check Karl’s model of sieving, I’ve built a significantly simpler version. The goal is to investigate the potential benefits of thinner membranes in dead-end filtration and separations. In my model 1 ml of…
Posted in NRG
