Introduction: This post presents a comprehensive protocol detailing an in vitro seeding and culturing method tailored for diverse cellular monolayer and tissue interfaces. These interfaces necessitate varying culturing conditions and extended timeframes, facilitated through modular device utilization. The methodology focuses…

The Burden of Tendon Injuries on HealthCare: Acute and chronic tendon injuries commonly affecting the working-age population are frequently work-related and have negative socioeconomic outcomes such as productivity loss, income loss, and unemployment(O’Hara et al., 2020). Tendon injuries are often…

Background: The human Tendon-on-Chip (hToC) spans collaboration between the Center for Musculoskeletal Research (CMSR) at the UR and the McGrath lab to develop an in vitro platform to study inflammation, fibrosis, and cell-cycle regulation in fibrovascular tendon healing. Interaction between…

Just wanted to drop this data here in case it may be useful for others in the lab. I calculated the volumetric flow rates for one of the peristaltic pumps used in the lab for the flow circuit in cell-culture.…

Introduction: Transforming Growth Factor -β1 (TGF-β1) is a key player in the induction and progression of fibrosis in many tissues. This factor has also been established as a regulator in the development of fibrotic diseases for its involvement of different…

This post serves as an introduction to the uni-axial motion envisioned to be integrated into the tendon-on-chip platform. As discussed previously we are working in junction with Dr. Awad from the Center for Musculoskeletal Research (CMSR) center at UR to…

This is my draft presentation for my CMSR presentation on December 4th. Link

This post serves as a summary of the work done during my rotation in the McGrath lab this summer. Over the course of six weeks, I shadowed projects covered in the lab along with the specializations of microfluidic devices and…