The goal of the blood brain barrier device is to co-culture cells in a closed system, with the apical chamber under flow conditions, while still being able to access either chamber for media changes or to introduce new solutions.  Electrodes…

One aspect of the blood brain barrier device is that it be a closed flow system.  This would not only better mimic an in vivo environment, but also maintain Sema4D activity, negatively affecting endothelial cell junctions and providing a target…

A quick recap:  Vaccinex has asked the lab to design a closed system device with the capability to co-culture on microporous membranes.  This device would be used to mimic the blood brain barrier, with endothelial cells cultured on the apical…

Vaccinex has developed an antibody, VX15/2503, for Semaphorin 4D, a molecule implicated in axonal guidance mediation and blood brain barrier (BBB) disruption.   The role of SiMPore in its partnership with Vaccinex is to produce a workable model of the BBB,…