Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since. This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.

Tour de force analysis of NPN/NPN-O pores

Many thanks to JK, Dean and Gunner (Webster HS) for compiling this table. Take homes … NPN-O has smaller pore sizes, lower porosity than NPN at the same thickness (50 nm). All materials have slightly asymmetric pores (~ R1/R2 =

Posted in NRG

NPN Clogging with Particle Size and Concentration (FOW)

This figure appears in our 2016 JMS paper and describes the clogging behavior of NPN with a 37 nm average pore size. The y-axis is the volume of filtrate after 1 min of forward centrifugation at 690g (3000 RPM). The

Posted in Knowledge (Public)

PEG-NPN for Reduced Protein Binding

Hopefully in the next week we will be submitting the following manuscript … X. Li, D. Johnson, W. Ma, H. Chung, J. Getpreecharsawas, J.L. McGrath, A.A. Shestopalov, Modification of Nanoporous Silicon Nitride with Stable and Functional Organic Monolayers, ACS Chemistry

Posted in NRG

Rapid (and reversible) Vacuolization of Brain Endothelial Cells under Flow

The following contain updates from a group of Swiss collaborators working with NPN for a BBB mimetic. The movies are important because they demonstrate T-cell/endothelial interaction including transmigration and because they show how using vacuum pressure can rapidly cause vacuoles

Posted in NRG

Ultrathin Polymer Membranes with patterned, micrometric pores for organs-on-chip

Paper for Friday’s Journal Club … Watch this space for a summary and analysis. Pensabene(Hofmeister)ACSAMI16 Synopsis 2um(?) pores in 100 nm thick PLLA. Very, very low porosity. Fabricated with a PVA microneedle mold produced with femto second laser. Microfluidic device

Posted in NRG

Solid- State Nanopores Integrated with Nanoporous Membranes for Enhanced Single-Molecule Counting of Low-Abundance Biomarkers

We are putting the final touches on a submission to NIH based on our work with Vincent Tabard-Cossa in Ottawa. I want to provide everyone with a small overview. The basic premise is that solid nanopores (ssNPs) are the right

Posted in NRG

Predicting the failure of silicon nanomembranes in burst pressure studies

After years of on again/ off again work – dating all the way back to the earliest days of the NRG – we have finally submitted a manuscript on membrane mechanics. The story of this manuscript is a remarkable one:

Posted in NRG

The importance of permeable substrates for proper vascular endothelial barrier function (preview)

This data comes from our collaborators in Switzerland who are working on a BBB culture model using NPN. In this study they are looking at the effects of co-culture on barrier function. The co-culture is with pericytes and a vascular

Posted in NRG

Journal Club: Preview from Sabrina Leslie – CLiC with flow

LabChip_20160430

Posted in NRG

‘HTTP error’ when trying to upload images

Hello everyone,   After some work on GoDaddy’s side, we have fixed the HTTP error when trying to upload images. Please let me know if you encounter this issue in the future. Cheers!

Posted in NRG
0
    0
    Your Cart
    Your cart is emptyReturn to Shop