Author: Jim
Professor McGrath holds a BS degree in Mechanical Engineering from Arizona State and a MS degree in Mechanical Engineering from MIT. He earned a PhD in Biological Engineering from Harvard/MIT's Division of Health Sciences and Technology. He then trained as a Distinguished Post-doctoral Fellow in the Department of Biomedical Engineering at the Johns Hopkins University. Professor McGrath has been on the Biomedical Engineering faculty at the University of Rochester since 2001 where he also served as the director of the graduate program in BME for more than a decade and currently serves as Associate Director of the URNano microfab and metrology core. Professor McGrath also has faculty affiliations with many other programs at UR including the Material Research Program, the Environmental Health and Sciences Center, the Biochemistry and Biophysics program, and the Musculoskeletal Research Center. McGrath's graduate, post-doctoral, and early faculty research was focused on quantitative experiments and mathematical modeling of cell migration covering molecular, cellular, and multi-cellular phenomena. This was true until 2007 when he, along with Professor Philippe Fauchet (now Dean at Vanderbilt) and PhD students Tom Gaborski (RIT) and Chris Streimer (Adarza), discovered a means to self-assembled nanopores in 15 nm thick free-standing silicon and demonstrated the remarkable transport properties of the new material in a Nature paper. This seminal discovery led to the creation of the multidisciplinary Nanomembrane Research Group (NRG) and the founding of SiMPore Inc. in the same year. The NRG and SiMPore have been dedicated to the advancement of ultrathin membrane technologies and exploring all of their potential applications ever since. This blog also dates back to 2007 and has had contributions from more than 100 students, faculty, scientists, engineers, and entrepreneurs. It contains over 2,500 pages and posts logging progress large and small over all these years. Yet somehow it feels like we are just getting started.

Pore Analysis for Wafer 1383 (Low Porosity Dual Scale)

From SiMPore’s Basecamp thread … These are the nanopore characteristics. So between 14% and 20% porosity across the wafer and between 43 nm and 50 nm average pore size. So a little under-sized. I hope T-Cells and Monocytes can get

Posted in memBrains, NRG

Table of Gas Permeance and Water Permeabilities for Various Nanomembranes

Wright, E., Miller, J.J, Csorda, M.. Gosselin, A.R., Carter, J.A., McGrath, J.L., Latulippe, D.R., Roussie, J.A. (2020) Development of Isoporous Microslit Silicon Nitride Membranes for Sterile Filtration Applications Biotechnology & Bioengineering https://doi.org/10.1002/bit.27240 DesOrmeaux, J. P., Winans, J. D., Wayson, S.

Posted in Knowledge (Public)

Modular assembly of the µSiM

Design and Manufacturing Plans from Aline: 2019-09-23 Rochester Assembly Step by Step Prototype Runs @ ALine Post-fabrication assembly (cutting with lower power to eliminate bubbles) …  

Posted in NRG

Large Pores Dominate Flow Through Nanomembranes (FOW)

Because of the non-linear dependence of volumetric flow rate on pore size … where t is the membrane thickness and r is the pore radius, large pores contribute disproportionately to the total flow through a membrane than small pores. The

Posted in Knowledge (Public)

eLIFE submission: A silicon nanomembrane-based in vitro platform to visualize immune cell trafficking across the human blood-brain barrier

We have been collaborating with Britta Engelhardt’s group at the University of Bern in Switzerland since Tejas and I met them at the CNS Barriers conference in Paris in 2015. They are interested in studying live T-cell transmigration across human

Posted in NRG

Why Flow Benefits Adhesion Based Sensors

The solution to the problem of diffusion from a semi-infinite solution to a perfectly absorbing surface is found on page 32 of Crank’s classic text (The Mathematics of Diffusion): (1)   Where D is the diffusion coefficient is the initial

Posted in Knowledge

How a Nanomembrane Prefilter can Enhance Electrophoretic Sensor Capture Under Flow (Part 1)

This will be at least a three part series. Here in Part I, we will establish why adding flow to electrophoretic sensor (ssNP) is a bad idea. In Part II we will show why microfluidics is a benefit to adhesion-based

Posted in Knowledge, NRG

The role of tRNAs on Cell Phenotypes

1-5-2018 Final tRNA Presentation – By Jon Flax (Beckham Group) Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression  

Posted in NRG

Why nanomembranes will not make good virus filters, but just might make great sterile filters.

We have been in discussions with a large membrane company (lets call them Big Filter Inc.) on the topic of using our membrane for virus applications. Josh Miller did a rather remarkable thing and affixed 5.4 mm NPN chips into

Posted in Knowledge

ICOM 2017

Grand Ballroom A Chair: Baoxia Mi & Zhiping Lai 09:00-09:25 [O8.01] Synthesis of graphene oxide membranes and their behavior in water and isopropanol A. Aher*1, Y. Cai1, M. Majumder2, D. Bhattacharyya1 1University of Kentucky, USA, 2Monash University, Austria 09:25-09:50 [O8.02] Carbon

Posted in NRG
0
    0
    Your Cart
    Your cart is emptyReturn to Shop