NOTE: Some of the ideas in this post are borrowed and rephrased from prior posts by Molly and Alec and our paper Khire et al. 2020. The purpose of this thread is to explain things anew with an eye on…
Tag: µSiM permeability
Theoretical Underpinnings of Small Molecule Permeability Measurements in the µSiM (Part 1: Approach)
10 kDa Small Molecule Permeability Optimization
Introduction A healthy blood-brain barrier is not permissive to most small molecules, but during inflammation, tight junctions weaken and the barrier becomes more permissive. We have developed an in situ permeability assay that tracks diffusion across a cell monolayer and…
