INTRODUCTION The blood-brain barrier (BBB) is a highly selective endothelial barrier that serves a crucial role in maintaining tissue homeostasis in the brain. Many current models, however, suffer from low TEER and permeability values far greater than physiological levels. Recently,…

In pursuit of an extremely sensitive biomarker capture sensor, I have been tasked with chemically functionalizing the surface of our membranes. Our end goal is to attach antibodies to the surface of our membranes which can be used to selectively…

Here are the figures for Tejas’ paper that is in the final stage of drafting:

Silicon nanomembranes are ultrathin, free-standing structures that vary from 10 – 100 nm in thickness. These membranes are at least 1 order of magnitude thinner than the thinnest polymeric membranes. Pores can be manufactured on these membranes to have diameters…

Introduction In a previous post I introduced the concept of endothelium apicobasal polarity and the potential to utilize this concept for future sepsis drug development: Endothelium Apicobasal Polarity Regulates the Innate Immune Response In Vitro [In Progress] In this post,…

Hello Everyone, Here is a summary of my trip to Nashville to learn about extracellular vesicles in cancer and present my work on isolation of nanoparticles/EVs using ultrathin nanomembranes.  Main points of the conference:  This conference was about EVs in…

Hi everyone, One of the objectives in the last aim of my PhD is to investigate the effect of soluble factors secreted by adipose derived stem cells (ADSCs) on wound recovery of fibroblasts (FBs). We have categorized these soluble factors…