The typical dialysis center experience targets a urea clearance value of KT/V = 1.4 (KT/V is explained by Dean here). We can use this knowledge to solve for the clearance rate of a typical dialysis center experience. Assuming 40 L…
Category: Knowledge
What is a glomerulus and where is it? How many are there?
The Bowman’s Capsule contains the Glomerulus, these are both part of a nephron of which the kidney has a gazillion. (The real estimate is the each kidney contains a million nephrons) Here are some pics to orient you. These give…
Posted in Knowledge
Liftoff Proposal Submitted to NSF SBIR Program
SiMPore submitted a Phase I SBIR proposal to NSF for liftoff of microporous silicon oxide and nanoporous nitride. This is a resubmission of the NSF Nanomanufacturing proposal that Tom and Bob submitted last Oct. and just heard last week that…
Posted in Knowledge
PEGS 2014
Protein and Antibody Engineering Summit – PEGS 2014 Our Poster: PEG2014_posterE Below are a couple of presentations from the Protein Aggregation and Stability session that I will summarize. Marszal_Ewa Singh_Satish Filipe_Vasco
Posted in Knowledge
Using Standard Deviation to Determine Sig Figs
As part of the decision letter on Barrett’s ancient vacuole manuscript, the editor sent a little tutorial from the University of Texas on significant digits and standard deviations. Apparently ACTA Biomaterialia looks at this carefully and found we needed a…
Brainstorming Topic For Visit With Vincent Tabard-Cossa
During our meeting with Vincent Tabard-Cossa from U Ottawa, we are going to explore the concept of using nano porous silicon nitride membranes in electronic detection schemes for identifying nucleic acid:small molecule complexes. The concept was demonstrated by Wanunu et…
Posted in Knowledge
Protein Adsorption (are we saturating the substrate?)
Hi all, Today I would like to briefly mention the important parameters to consider when saturating a substrate with proteins by simple adsorption. More specifically, the concentration and time required to fully saturate a substrate ares estimated for systems with different…
Posted in Knowledge, Knowledge (Public)
NSF proposal on Catalytic Membrane Reactors
I submitted a proposal last week with Tom & I as co-PI’s to NSF’s Process Reaction Engineering division in CBET. Novel Catalytic Membrane Reactor Based on Ultra-thin Palladium Film Supported on Nano-structured Inorganic Membrane I’m attaching the intro. paragraph and…
Modeling EOF and Electric Field Gradient at a Microporous Membrane
I used COMSOL for finite element analysis (FEA) modeling of EOF and DEP at a microporous membrane in a PDMS microfluidic channel. Effects of two parameters were determined: Membrane thickness, and spacing between pores. The modeled membranes had a 25×25…
Hemodialysis in the rat animal model
I found some good descriptions of hemodialysis experiments using rats. They all use a method possibly first described by (Rockel et al., 1978). (Galons, Trouard, Gmitro, & Lien, 1996) at U of Arizona used nephrectomized male Spraque-Dawley rats (Holtzmann Co.,…
