Administrative: Molly Van Wyk is no longer TraCe-bMPS admin. Assumed Bonnie’s job as Sr. Admin in BME. Will continue to help until position is replaced. Quality Systems meetings are moving to Wednesdays only: 9:30 -10:00 AM Progress meetings will be…

We’ve long speculated that adding fluid flow over our tissue models would reduce the concentration of pro-inflammatory factors secreted in response to inflammatory challenges, dampening the overall inflammatory state compared to static culture. We now have evidence that this is…

Introduction Over the past few months, I have been characterizing and comparing iPSC-derived monocytes (iMonocytes) with peripheral blood-derived (PB) monocytes. As I wrap up these experiments, we’ve decided to look at marker expression on iMonocytes and PB monocytes once they…

Image analysis for force from videos of deflected PDMS beams In the summer, Yimei Du from University of Rochester visited Truskey lab to help with the μSiM Vasc-SkM system. Besides working with the chip culture, she helped improve the image…

LoI and QS Slides for NIH monthly mtg 28 Aug 2025 Letters of Intent Draft sent to C-Path on August 15 CRS/ICANS JDM    

Status of the Quality System Team – June 27, 2025 Quality System Update – 27 June 2025

Work in progress … **************** T cell–Engaging Immunotherapies Pose a Predictable but Complex RiskT cell–engaging bispecific antibodies (BsAbs), particularly those targeting CD3 and a tumor-associated antigen, have emerged as a powerful class of immunotherapies. These agents leverage endogenous T cells…

Since the last TraCe-bMPS update in April, we continued to explore different conditions to optimize the μSiM hVasc-SkM systems to obtain stable results.  Enhanced imaging for PDMS beams with Rhodamine staining  Previously we established a MATLAB program that detects the…