I assembled two 2-chip dialyzers using the thicker, 75-nm NPN membrane chips (10 mm long multichannel, 22 mm x 24 mm). The dialyzers were pumped full of IPA, to fill with fewer bubbles, then infused with PBS for at least…
Tag: Hemodialysis
Surface Modification for Hemodialysis
We are continuing to work with the Shestopalov lab on surface modifiation of hemodialysis filters to prevent adhesion and activation. Jim recently presented our status and strategy (PDF) to the Technical Development Fund and was awarded the balance of the award,…
Urea Clearance: First Animal Study Results
BOTTOM LINE: We had great results from the small number of nanoporous membranes used to clear urea from Sprague-Dawley rats. We are clearing Urea better than commercial materials. (see fig) Recap of previous work: First we leaned how to set…
Sham Dialysis Study
We performed four hours of sham dialysis, using two non-porous nitride membranes. The set-up is described in an earlier post. Blood samples were taken when the animal was received, after one week of the adenine containing diet, then at 1 hour…
Small Animal Model Hemodialysis Set-Up
Sprague-Dawley rats will be purchased from Harlan. These pre-manipulated animals will have been catheterized prior to shipment. We will feed them an adenine rich diet to induce uremia, high levels of urea in the blood. Once uremic, a rat will…
Review: Blood Purification 2013
In vitro Clearance and Hemocompatibility Assessment of Ultrathin Nanoporous Silicon Membranes for Hemodialysis Applications Using Human Whole Blood Morteza Ahmadi Maud Gorbet John T.W. Yeow Department of Systems Design Engineering and Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ont. , Canada Summary Two…
Hemo biometrics for various animals
In determining an appropriate animal model for hemodialysis efficacy, several metrics need to be compared to the human vasculature. Blood volume, blood pressure, and heart rate could effect the suitability of these animals to model clinical hemodialysis. Blood volume can…
Paper Review… Human Nephron Filter: Nissenson(Watts) UCLA
In researching for the paper for Advances in Chronic Kidney Disease (ACKD) I’ve run across some interesting papers. Here is one describing a proposed Human Nephron Filter… Human nephron filter proposed by Nissenson1 (1) 1Division of Nephrology, Department of Medicine,…
