Introduction The invasion of Staphlyococcus aureus into the cracks of cortical bone leads to osteomyelitis, a devastating disease often resolved by amputation [1]. The μSiM platform has been used to study the genetic mechanisms of S. aureus invasion. The membrane…

Introduction Extracorporeal membrane oxygenation (ECMO) devices are used to supply oxygen to patients when they are unable to get sufficient oxygen through their lungs. Miniaturizing an ECMO device could be beneficial for neonatal patients, as it would require less blood…

The Burden of Tendon Injuries on HealthCare: Acute and chronic tendon injuries commonly affecting the working-age population are frequently work-related and have negative socioeconomic outcomes such as productivity loss, income loss, and unemployment(O’Hara et al., 2020). Tendon injuries are often…

The premise of this project is built around the ideas that our membranes can: Be used as concentrators for very dilute targets Catch and hold particles for further processing on the membrane Here, we wish to test these ideas for…

Thanks to our collaborators at the University of Chicago we have now used NPN to demonstrate sodium/hydrogen exchange functions at the level of single EVs. This is first-of-a-kind evidence of protein function in individual EVs. It will be officially published…

Introduction This post is meant to introduce the new NPN-enabled slide-based devices produced by Ibidi. These devices feature an NPN membrane and microfluidic channels positioned perpendicular to one another formed by PSA and COP layers (Figure 1). Channels above and…

With our virus sensor paper now published, my journey with virus diagnostics, at least for now, comes to an end. Keeping with the theme of modifying silicon surfaces for interaction with pathogens, I am now switching gears to developing models…

The physical properties of the extracellular matrix such as stiffness, viscoelasticity, fiber diameter, and chemical composition are well known as important modulators of cell behavior in vivo. Therefore, over the past decade, there has been a major emphasis on characterizing the…

  Starting in July of 2021, we began a new idea fabricating the nano pocket membrane to capture and release the EVs. From then until now we have successfully fabricated nano pocket membranes by using a lithography method. We faced…